董肖椿
药物化学, 副教授, 硕士生导师

姓      名

 董肖椿

性      别

 男

职      称

 副教授

学      历

 理学博士(药物化学)

电      话

 021-51980123

传      真

 

电子邮件

 xcdong@fudan.edu.cn

个人主页

 

通讯地址

 上海市浦东新区张衡路826号实验南楼417室

 

教育经历
2004.9.-2007.6:澳门新葡亰www496cn药物化学专业,博士

2000.9.-2003.6:澳门新葡亰www496cn药物化学专业,硕士

1993.9.-1997.6:华东师范大学化学系化学专业,学士

工作经历
2013.12- 至今:澳门新葡亰www496cn药物化学教研室,副教授

2008.9 -2009.9:美国明尼苏达大学澳门新葡亰所有网址药物化学系,博士后

1997.7- 2013.11:澳门新葡亰www496cn药物化学教研室,助教/讲师

承担科研项目情况
1. 国家自然科学基金面上项目(21572037),新结构类型Hedgehog通路抑制剂的设计、合成和构效关系研究,主持

2. 上海市自然科学基金面上项目(12ZR1403300),含氮杂四元环骨架的新型Hedgehog通路抑制剂的设计、合成及抗肿瘤活性研究,主持

3. 国家自然科学基金面上项目(81573363),基于水淬灭近红外荧光探针的口服脂质纳米给药系统体内命运与作用机制研究,参与

4. 国家自然科学基金面上项目(81872816),新型水淬灭近红外荧光探针的设计及其在纳米粒体内过程研究中的应用,参与

研究方向
1. 基于分子靶向、肿瘤信号通路及免疫相关小分子抗肿瘤药物先导化合物研究

2. 有机药物合成方法研究

代表性论著
1. Mingfei Zhu, Hong Wang, Chenglin Wang, Yanfen Fang, Tong Zhu, Weili Zhao, Xiaochun Dong*, Xiongwen Zhang*, L-4, a well-tolerated and orally active inhibitor of hedgehog pathway, exhibited potent anti-tumor effects against medulloblastoma in vitro and in vivo. Front. Pharmacol.,2019, 10, e89.

2.Xiaochun Dong, Chenglin Wang, Zhongjian Chen*, Weili Zhao*. Overcoming the Resistance mechanisms of Smoothened inhibitors, Drug Discovery Today2018, 23: 704-710

3. Chenglin Wang, Mingfei Zhu, Xiuhong Lu, Hong Wang, Weili Zhao, Xiongwen Zhang*, Xiaochun Dong*. Synthesis and evaluation of novel dimethylpyridazine derivatives as hedgehog signaling pathway inhibitors. Bioorg. Med. Chem. 2018, 26, 3308-3320

4. Xiuhong Lu, Zhongjian Chen*, Xiaochun Dong*, Weili Zhao*. Water -Soluble Fluorescent Probe with Dual Mitochondria/Lysosome Targetability for Selective Superoxide Detection in Live Cells and in Zebrafish Embryos. ACS Sensors,2018, 3: 59-64

5. Xiuhong Lu, Yuanqiu Peng, Chenglin Wang, Jun Yang, Xiaolong Bao, Qian Dong, Weili Zhao*, Wenfu Tan*, Xiaochun Dong*. Design, synthesis, and biological evaluation of optimized phthalazine derivatives as hedgehog signaling pathway inhibitors. Eur. J Med. Chem.2017, 138, 384-395.

6. Feng Yang, Wen Wang, Kaidi Li, Weili Zhao*, Xiaochun Dong*. Efficient one-pot construction of unsymmetrical disulfide bonds with TCCA. Tetrahedron Lett.,2017, 58, 218–222.

7. Xiaolong Bao, Yuanqiu Peng, Xiuhong Lu, Jun Yang, Weili Zhao*, Wenfu Tan*, Xiaochun Dong*. Synthesis and evaluation of novel benzylphthalazine derivatives as hedgehog signaling pathway inhibitors. Bioorg. Med. Chem, Lett.2016, 26, 3048-3051

8. Lu Xiuhong, Wang Wen, Dong Qian, Bao Xiaolong, Lin Xianfeng, Zhang Weixing, Dong Xiaochun*, Zhao Weili*. A multi-functional probe to discriminate Lys, Arg, His, Cys, Hcy and GSH from common amino acids. Chemical Communications,2015, 51(8): 1498-1501

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